The use of piperacillin–tazobactam in neonatal and paediatric patients

@article{Wolf2009TheUO,
  title={The use of piperacillin–tazobactam in neonatal and paediatric patients},
  author={Maria F Wolf and Arne Simon},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2009},
  volume={5},
  pages={57 - 69}
}
  • M. Wolf, A. Simon
  • Published 1 January 2009
  • Medicine
  • Expert Opinion on Drug Metabolism & Toxicology
Background: Piperacillin–tazobactam (PIP/TAZO) has been extensively used in adults with nosocomial infections and with fever and neutropenia. The available data considering the use of PIP/TAZO have not been reviewed in detail. Objective: Review discussing the use of PIP/TAZO in neonatal and paediatric patients. Methods: Medline search focusing on articles published in English. Owing to the paucity of randomized controlled trails, uncontrolled studies and case series were included. Results… 
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Dose-Exposure Simulation for Piperacillin-Tazobactam Dosing Strategies in Infants and Young Children.

TLDR
To determine appropriate TZP dosing strategies in children 2 months - 6 years according to age and different minimal inhibitory concentrations, post-hoc pharmacokinetic parameter estimates were generated using published clearance and volume of distribution data.

Determination of Free and Total Piperacillin–Tazobactam in Plasma by HPLC–MS–MS: An Adapted Method for Neonates

TLDR
The validation results of this analytical method made it feasible for being used in a further pilot study of population pharmacokinetics of piperacillin–tazobactam in neonates.

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TLDR
It is concluded that P/T in association with amikacin is microbiologically and clinically efficacious and safe in the treatment of sepsis in newborns and within 48–72 h of therapy in 93% Gram-negative organisms.

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TLDR
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TLDR
It is suggested that piperacillin/tazobactam may be a useful antimicrobial agent in neonatal infections caused by beta-lactamase-producing organisms.

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  • C. ViscoliA. Cometta T. Calandra
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
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TLDR
It was concluded that piperacillin-tazobactam could be considered as monotherapy for patients with high-risk febrile neutropenia.

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TLDR
This study suggests that piperacillin-tazobactam in association with netilmicin presents a satisfactory efficacy and a good tolerance as empirical therapy for febrile neutropenic children.

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TLDR
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TLDR
Piperacillin-Tazobactam (Pip-TZ) appears to be a safe, and feasible alternative in pediatric cancer patients with febrile neutropenia <25 months of age suggesting that the inclusion of children of all age groups in future prospective controlled studies evaluating Pip-Tazer is justified.

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TLDR
Based on the safety and efficacy results from this study, the advantages of using a single agent for the treatment of mixed infections of the peritoneal cavity and its potential activity against resistant organisms are believed to be significant.

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TLDR
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TLDR
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