The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery.

@article{Pendergrass2011TheUO,
  title={The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery.},
  author={Sarah A. Pendergrass and Kristin Brown-Gentry and Steven M. Dudek and Eric S Torstenson and Jos{\'e} Luis Ambite and Christy L. Avery and Steven Buyske and C Z Cai and Megan Dann Fesinmeyer and Christopher A. Haiman and Gerardo Heiss and Lucia A. Hindorff and C-N Hsu and Rebecca D. Jackson and Charles Kooperberg and Lo{\"i}c Le Marchand and Yanzhu Lin and Tara Cox Matise and Larry Moreland and K Monroe and Alex P. Reiner and Robert T. Wallace and Lynne Ross Wilkens and Dana C. Crawford and Marylyn DeRiggi Ritchie},
  journal={Genetic epidemiology},
  year={2011},
  volume={35 5},
  pages={410-22}
}
The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome-wide association studies (GWAS) have been used to investigate the relationship between genetic variation and single diseases/outcomes. A novel approach has emerged combining both the exploration of phenotypic structure and genotypic variation, known as the phenome-wide association study (PheWAS). The Population Architecture using Genomics and Epidemiology (PAGE) network is a National… CONTINUE READING
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National Health and Nutrition Examination Survey (NHANES) Stored Biologic Specimens: Guidelines for Proposals to Use Samples and Proposed Cost Schedule

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