The use of pharmacokinetics as an interpretive and predictive tool in chemical toxicology testing and risk assessment: a position paper on the appropriate use of pharmacokinetics in chemical toxicology.

Abstract

It has been recognized for several decades in the pharmaceutical industry that the safety evaluation of pharmacological agents must include pharmacokinetic (PK) studies, which are designed to determine the rate of absorption, distribution, metabolism, and excretion (ADME). In recent years the importance of such ADME studies in toxicology has also become… (More)

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@article{Frantz1994TheUO, title={The use of pharmacokinetics as an interpretive and predictive tool in chemical toxicology testing and risk assessment: a position paper on the appropriate use of pharmacokinetics in chemical toxicology.}, author={Stephen W. Frantz and Patrick W. Beatty and J. Caroline English and Susan Hundley and Alyson G. Wilson}, journal={Regulatory toxicology and pharmacology : RTP}, year={1994}, volume={19 3}, pages={317-37} }