The use of non-natural nucleotides to probe template-independent DNA synthesis.

Abstract

The vast majority of DNA polymerases use the complementary templating strand of DNA to guide each nucleotide incorporation. There are instances, however, in which polymerases can efficiently incorporate nucleotides in the absence of templating information. This process, known as translesion DNA synthesis, can alter the proper genetic code of an organism. To… (More)

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Cite this paper

@article{Berdis2007TheUO, title={The use of non-natural nucleotides to probe template-independent DNA synthesis.}, author={Anthony J. Berdis and David C. McCutcheon}, journal={Chembiochem : a European journal of chemical biology}, year={2007}, volume={8 12}, pages={1399-408} }