The use of natural products in colorectal cancer drug discovery.

  title={The use of natural products in colorectal cancer drug discovery.},
  author={Koh Miura and Masayuki Satoh and Makoto Kinouchi and Kuniharu Yamamoto and Yasuhiro Hasegawa and Yoichiro Kakugawa and Masaaki Kawai and Kiyoshi Uchimi and Hiroki Aizawa and Shinobu Ohnuma and Taiki Kajiwara and Hiroto Sakurai and Tsuneaki Fujiya},
  journal={Expert opinion on drug discovery},
  volume={10 4},
INTRODUCTION Natural products (NPs) are evolutionarily designed and contain more complex and challenging structures than synthetic compounds. Since the 1980s, the pharmaceutical industry has gradually shifted to a strategy of developing targeted agents by screening libraries of synthetic compounds. However, NPs have recently received renewed focus as a rich repository for drug discovery. Irinotecan was developed as a derivative of camptothecin and was applied in standard regimens for metastatic… CONTINUE READING
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