Corpus ID: 6803549

The use of mushroom glucans and proteoglycans in cancer treatment.

@article{Kidd2000TheUO,
  title={The use of mushroom glucans and proteoglycans in cancer treatment.},
  author={P. Kidd},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  year={2000},
  volume={5 1},
  pages={
          4-27
        }
}
  • P. Kidd
  • Published 2000
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
Immunoceuticals can be considered as substances having immunotherapeutic efficacy when taken orally. [...] Key Result PSK and PSP boosted immune cell production, ameliorated chemotherapy symptoms, and enhanced tumor infiltration by dendritic and cytotoxic T-cells. Their extremely high tolerability, proven benefits to survival and quality of life, and compatibility with chemotherapy and radiation therapy makes them well suited for cancer management regimens.Expand
Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China.
TLDR
The clinical studies support PSP being a potential immunotherapeutic, however, the complicated chemical and multiple pharmacological properties of PSP need to be investigated further. Expand
POLYSACCHARIDE FROM LENTINUS EDODES FOR INTEGRATIVE CANCER TREATMENT : IMMUNOMODULATORY EFFECTS ON LYMPHOCYTE POPULATION
Background: Fungal alpha and β-glucans have been used as therapeutic support for thousands of years in Eastern culture. Lentinan, the backbone of β-(1, 3)-glucan with β-(1, 6) branch es, is the mainExpand
[Immunomodulatory and antitumor properties of polysaccharide peptide (PSP)].
TLDR
Polysaccharidepeptide is a protein-polisaccharide complex with a molecular weight 100 kDa derived from Coriolus versicolor mushroom that inhibits the growth of cancer cells in in vitro and in vivo settings as well as decreases cancer treatment-related adverse side effects. Expand
Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans.
TLDR
The three neutral proteoglycans derived from the mushroom (P. ostreatus) mycelia could be used as immunomodulators and anti cancer agents, and showed the presence of large number of terminal sugar with glucose/mannose. Expand
An Evidence-based Perspective of Lentinus Edodes (Shiitake Mushroom) for Cancer Patients
TLDR
The antitumor activity and immunomodulating action of biologically active polysaccharides, mostly β-glucans, from shiitake mushroom fruit bodies and/or cultured mycelium based on experimental and clinical findings are summarized. Expand
Coriolus versicolor: A Medicinal Mushroom with Promising Immunotherapeutic Values
TLDR
There has been sufficient scientific evidence to support the feasibility of developing at least some of aqueous CV constituents into an evidence‐based immunodulatory agent. Expand
Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum.
TLDR
In vivo administration of GSG potentiated the Con A-induced proliferative response of splenocytes and induced anti-tumor activity against Lewis lung cancer in mice, suggesting that GSG is an effective immunomodulator and may be a promising adjuvant remedy for anti-Tumor therapies. Expand
Mushroom polysaccharides as potential prebiotics with their antitumor and immunomodulating properties: A review
TLDR
The potential of mushroom polysaccharides as prebiotics with their antitumor and immunomodulating properties for the development of nutraceutical foods and drugs is explored. Expand
The effect of polysaccharide peptide and taxol on human solid tumor tissue in vitro
TLDR
In this study, taxol was significantly effective on tumors in younger aged, low tumor grade; ER and PR negative group’s subjects and PSP demonstrated similar results and also suppresses the activity of breast solid tumor. Expand
Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides
  • S. Wasser
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
  • 2002
TLDR
The present review analyzes the pecularities of polysaccharides derived from fruiting bodies and cultured mycelium in selected examples of medicinal mushrooms and concludes that high molecular weight glucans appear to be more effective than those of low molecular weight. Expand
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TLDR
The antitumor mechanisms of several species of whole mushrooms as well as of polysaccharides isolated from Lentinus edodes, Schizophyllum commune, Grifola frondosa, and Sclerotinia sclerotiorum are mediated largely by T cells and macrophages, and the means by which they modulate the immune system and potentially exert tumor-inhibitory effects are reviewed. Expand
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This review highlights some of the recently isolated and identified substances of higher Basidiomycetes mushrooms origin that express promising antitumor, immune modulating, cardiovascular andExpand
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Data suggest that immunopotentiation activity of PSK might be ascribed, at least in part, to stimulation of cytokine action and production, andPSK might have some unique structural features. Expand
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In Japan three different polysaccharide antitumor agents have been isolated from the fruiting body, mycelium, and cultured medium, from three mushroom species. Expand
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Through 485 cases of random double-blind clinical experiments, it has been proved that PSP can obviously improve the clinical symptoms of stomach, lung and esophagus cancer patients, lower the toxic and side effects of chemo- and radio-therapy and raise the life quality of patients. Expand
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TLDR
Lentinan exerts a prominent antitumor effect and prevents chemical and viral oncogenesis, and appears to represent a unique class of immunopotentiator, a T cell-oriented adjuvant. Expand
The effect and distribution of a protein-bound polysaccharide preparation, PSK (Krestin), intratumorally injected prior to surgery into gastric cancer patients.
TLDR
Investigation of the kinetics and immune response augmenting effect of intratumorally injected PSK by immunohistochemical methods using anti-PSK antibody and various other antibodies found PSK-containing cells were located in the tumor tissues and follicular marginal zones of regional lymph nodes. Expand
Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin).
TLDR
The present study on the in vivo behavior of 14C-labelled PSK provides an important basis for further analysis of its pharmacological actions. Expand
Intratumoral administration of sizofiran activates Langerhans cell and T-cell infiltration in cervical cancer.
TLDR
The present study suggested that the LC and T-cell infiltrations in cancer tissues were augmented by intratumoral SPG administration at a certain concentration to improve the prognosis after multidisciplinary treatment of advanced cervical cancer. Expand
Activation by the protein-bound polysaccharide PSK (krestin) of cytotoxic lymphocytes that act on fresh autologous tumor cells and T24 human urinary bladder transitional carcinoma cell line in patients with urinary bladder cancer.
TLDR
The results indicate that the antitumor activity of PSK may be in part mediated through activation of tumor killing system independent of IFN-alpha, IFn-gamma and IL-2. Expand
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