The use of mouse models to better understand mechanisms of autoimmunity and tolerance.

@article{Miyagawa2010TheUO,
  title={The use of mouse models to better understand mechanisms of autoimmunity and tolerance.},
  author={Fumi Miyagawa and Jan Gutermuth and Hong Zhang and Stephen I. Katz},
  journal={Journal of autoimmunity},
  year={2010},
  volume={35 3},
  pages={192-8}
}
A major emphasis of our studies has been on developing a better understanding of how and why the skin serves as a target for immune reactions as well as how the skin evades becoming a target for destruction. For these studies we developed transgenic mice that express a membrane-tethered form of a model self antigen, chicken ovalbumin (mOVA), under the control of a keratin 14 (K14) promoter. K14-mOVA transgenic mice that express OVA mRNA and protein in the epithelia have been assessed for their… CONTINUE READING

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