The use of mid-trial reviews for design modifications in small scale clinical studies.

Abstract

Many clinical studies such as those in the areas of toxicology, early phase clinical trials and bioequivalence studies use small samples due to the high cost of experimentation. These studies test hypotheses based on small samples. These small samples result in low power and therefore even if the alternative hypotheses may be true the chance of it being… (More)
DOI: 10.1016/j.cct.2010.07.011

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