The use of membrane vesicles to study the NaCl/KCl cotransporter involved in active transepithelial chloride transport

Abstract

Properties of the NaCl/KCl cotransport system were investigated in isolated membranes by flux measurements and binding studies. Chloride competes with “furosemide-like loop diuretics” for its two binding sites at the cotransporter as evidenced by the decrease in piretanide sensitivity of sodium flux and inhibition of high affinity N-methylfurosemide binding… (More)
DOI: 10.1007/BF00581788

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