The use of medication in selective mutism: a systematic review

@article{Manassis2015TheUO,
  title={The use of medication in selective mutism: a systematic review},
  author={Katharina Manassis and Beate Oerbeck and Kristin Romvig Overgaard},
  journal={European Child \& Adolescent Psychiatry},
  year={2015},
  volume={25},
  pages={571-578}
}
Despite limited evidence, selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs) are used to reduce symptoms of selective mutism (SM) in children unresponsive to psychosocial interventions. We review existing evidence for the efficacy of these medications, limitations of the literature, and resulting treatment considerations. Bibliographic searches were conducted in Medline, Embase, PsycInfo, Web of Science and Cochrane up to June 2015. Two reviewers… 
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This article serves as a primer of historical and clinical presentations, empirical clinical profiles, clinical distinctions, assessment, and treatment related to the complexity of selective mutism.
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Selective mutism (SM) is a developmental disorder characterized by a child’s inability to speak in certain contexts and/or in the presence of unfamiliar interlocutors. This work proposes a
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References

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TLDR
Two of the five participants no longer met diagnostic criteria for selective mutism following less than 10 weeks of 100 mg sertraline treatment and a third participant was reported asymptomatic at 20 weeks poststudy.
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The findings suggest the potential benefit of SSRI treatment in severe SM, but randomized comparative treatment studies are indicated.
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TLDR
It is concluded that phenelzine can be an effective treatment for selective mutism, but because of the possibility of serious food and drug interactions and the necessary dietary restrictions, it should be reserved for cases that do not respond to behavior therapy and fluoxetine or other specific serotonin reuptake inhibitors.
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TLDR
Outcome data 1 year after having completed the 6-month course of CBT for 24 children with SM, aged 3–9 years (mean age 6.5 years, 16 girls), shows greater improvement in the younger children highlights the importance of an early intervention.
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