The use of low dose methotrexate in refractory sarcoidosis.

  title={The use of low dose methotrexate in refractory sarcoidosis.},
  author={Elyse E Lower and Robert P Baughman},
  journal={The American journal of the medical sciences},
  volume={299 3},
Symptomatic sarcoidosis is usually treated with glucocorticoids; however, glucocorticoids are associated with significant morbidity. Because low dose methotrexate has been successful in treating other inflammatory diseases, methotrexate was used in patients with persistent, symptomatic sarcoidosis. Fifteen patients with either progressive advancing disease or severe side effects with prednisone were treated with methotrexate for at least 6 months. In 13 of 14 evaluable cases there was… CONTINUE READING

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