The use of ketamine in complex regional pain syndrome: possible mechanisms

  title={The use of ketamine in complex regional pain syndrome: possible mechanisms},
  author={R. Schwartzman and G. Alexander and J. Grothusen},
  journal={Expert Review of Neurotherapeutics},
  pages={719 - 734}
  • R. Schwartzman, G. Alexander, J. Grothusen
  • Published 2011
  • Medicine
  • Expert Review of Neurotherapeutics
  • Complex regional pain syndrome is a neuropathic pain syndrome that is characterized by: severe pain beyond the area of injury; autonomic dysregulation; neurogenic edema; movement disorder; and atrophy and dystrophy. Ketamine is an open-channel NMDA blocker that only acts on those receptors whose Mg2+ block has been lifted. It is effective in the treatment of the syndrome when standard treatments have failed. Different protocols are utilized depending on the severity of illness. There have been… CONTINUE READING
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