The use of isotopes in the determination of absolute bioavailability of drugs in humans

@article{Lappin2006TheUO,
  title={The use of isotopes in the determination of absolute bioavailability of drugs in humans},
  author={G. Lappin and M. Rowland and R. C. Garner},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2006},
  volume={2},
  pages={419 - 427}
}
Absolute bioavailability studies in humans are not routinely performed as part of the drug registration process. They tend to be reasonably demanding, not least because toxicology data are required to support intravenous administration of a drug. Moreover, the classical crossover design of an absolute bioavailability study can suffer from artefacts caused by concentration-dependent pharmacokinetics. Many of the problems associated with absolute bioavailability studies can be alleviated using… Expand
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