The use of in vitro systems to assess cancer mechanisms and the carcinogenic potential of chemicals.

@article{Breheny2011TheUO,
  title={The use of in vitro systems to assess cancer mechanisms and the carcinogenic potential of chemicals.},
  author={Damien Breheny and Oluwatobiloba Oke and Stephen P. Faux},
  journal={Alternatives to laboratory animals : ATLA},
  year={2011},
  volume={39 3},
  pages={
          233-55
        }
}
Carcinogenesis is a highly complex, multi-stage process that can occur over a relatively long period before its clinical manifestation. While the sequence in which a cancer cell acquires the necessary traits for tumour formation can vary, there are a number of mechanisms that are common to most, if not all, cancers across the spectrum of possible causes. Many aspects of carcinogenesis can be modelled in vitro. This has led to the development of a number of mechanistically driven, cell-based… CONTINUE READING

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