The use of in vitro cytotoxicity measurements in QSAR methods for the prediction of the skin corrosivity potential of acids.


Quantitative structure-activity relationships (QSAR) methods have been derived that relate the severity of skin corrosivity (designated by the EC risk phrases R34 and R35) of acids to parameters that model their skin permeability and cytotoxicity. Skin permeability was modelled by log(octanol/water partition coefficient), molecular volume and melting point… (More)


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