The use of immunohistochemistry for biomarker assessment--can it compete with other technologies?

@article{Dunstan2011TheUO,
  title={The use of immunohistochemistry for biomarker assessment--can it compete with other technologies?},
  author={Robert W Dunstan and Keith A. Wharton and Catherine Quigley and Amanda Lowe},
  journal={Toxicologic pathology},
  year={2011},
  volume={39 6},
  pages={988-1002}
}
A morphology-based assay such as immunohistochemistry (IHC) should be a highly effective means to define the expression of a target molecule of interest, especially if the target is a protein. However, over the past decade, IHC as a platform for biomarkers has been challenged by more quantitative molecular assays with reference standards but that lack… CONTINUE READING