The use of hydrophilic lipophilic balanced (HLB) copolymer SPE cartridges for the extraction of diclofenac from small volume paediatric plasma samples.

Abstract

The extraction of diclofenac from spiked aqueous and plasma samples by liquid-liquid extraction (LLE) and solid phase extraction (SPE) methods is compared. The SPE methodology utilised a hydrophilic lipophilic balanced (HLB) copolymer as the extraction phase. Using a literature HPLC method, a calibration curve for diclofenac was constructed in the range 1.0… (More)

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Cite this paper

@article{Millership2001TheUO, title={The use of hydrophilic lipophilic balanced (HLB) copolymer SPE cartridges for the extraction of diclofenac from small volume paediatric plasma samples.}, author={Jeffrey Stuart Millership and Lesley G Hare and Mike Farry and Paul S. Collier and James C. McElnay and Michael D. Shields and D. J. Carson}, journal={Journal of pharmaceutical and biomedical analysis}, year={2001}, volume={25 5-6}, pages={871-9} }