The use of hybrid hybridomas to target human cytotoxic T lymphocytes.

@article{Lanzavecchia1987TheUO,
  title={The use of hybrid hybridomas to target human cytotoxic T lymphocytes.},
  author={Antonio Lanzavecchia and Doris Scheidegger},
  journal={European journal of immunology},
  year={1987},
  volume={17 1},
  pages={105-11}
}
This study describes a general strategy to produce hybrid monoclonal antibodies that are capable of targeting human cytotoxic T lymphocytes (CTL) against any cell carrying the appropriate target antigen. This is done by fusing a HAT-sensitive, G418-resistant anti-T3 hybridoma with immune spleen cells (or with other hybridomas) that produce antibodies against the desired target antigen. In the hybrid hybridomas the reassortment of Ig heavy and light chains results in the production of… CONTINUE READING
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