The use of human spleen imprints for routine testing for serum antinuclear factors by immunofluorescence.

  title={The use of human spleen imprints for routine testing for serum antinuclear factors by immunofluorescence.},
  author={Kathryn H. Svec},
  journal={American journal of clinical pathology},
  volume={47 4},
  • K. H. Svec
  • Published 1 April 1967
  • Medicine
  • American journal of clinical pathology
12 Citations
Antinuclear Antibodies Testing Method Variability: A Survey of Participants in the College of American Pathologists’ Proficiency Testing Program
Lack of uniformity in testing and reporting practice and lack of transparency in communicating the testing method may misdirect clinicians in their management of patients.
Untersuchungen zur Bedeutung des Fluoreszenz-Antiglobulintests und des Antiglobulin-Konsumptionstests zum Nachweis antinukleärer Serumfaktoren
The highest average Titres of the total antinuclear factors, as well as those of the IgG- and IgM-factors were encountered in patients with chronic liver diseases, the highest average titre of IgA-factor in patientsWith lupus erythematosus and the occurrence of “falsely positive” results was particularly high in Patients with hypergammaglobulinämie.
Anti-Ro/SSA antibodies. Association with a particulate (large speckledlike thread) immunofluorescent nuclear staining pattern.
It is suggested that anti-Ro/SSA antibodies and antibodies producing the particulate nuclear staining pattern on human spleen imprints are either one and the same or closely paralleling antibody systems.
Epidermal nuclear immunofluorescence on skin biopsy correlated with serum anti‐n‐RNP and is a useful marker for mixed connective tissue disease, however, it did not appear to serve as a specific marker for any one connectives tissue disease.
Antinuclear antibodies. I. Patterns of nuclear immunofluorescence.
Fifteen separate and distinct nuclear immun ofluorescent patterns have been identified by indirect immunofluorescence employing human spleen touch imprints as substrate, and these patterns have to be differentiated from those specifically associated with certain diseases.
A study of the immunologic aspects of chronic ulcerative colitis and transmural colitis.
Increasing evidence has come forth in recent years indicating that immunologic mechanisms deserve an important consideration in the pathogenesis of chronic ulcerative colitis, and its possible role as a diagnostic and prognostic tool in this disease remains unclear.
Antinuclear factor (ANF) test--its diagnostic value.
The ANF test was introduced in the Cleveland Clinic laboratories about three years ago, and the main purpose of this study was to analyze and to correlate clinically the first 500 consecutive ANF tests performed during the year 1967.