The use of human recombinant gonadotropin receptors to search for immunoglobulin G-mediated premature ovarian failure.

@article{Anasti1995TheUO,
  title={The use of human recombinant gonadotropin receptors to search for immunoglobulin G-mediated premature ovarian failure.},
  author={James N. Anasti and Melinda Flack and J{\"u}rg Fr{\"o}hlich and Lawrence M. Nelson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 3},
  pages={824-8}
}
Anti-FSH receptor antibodies, detected using animal systems, have been reported in a few patients with premature ovarian failure (POF). However, assays based on animal receptors may be inappropriate for detecting inhibiting antibodies in humans. Accordingly, we tested for interfering antibodies in patients with POF using a recombinant system expressing human (h) FSH and LH receptors. A mouse adrenal cell line transfected with the hFSH receptor (Y1-hFSHR) exhibits a dose-dependent increase in… CONTINUE READING

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Premature ovarian failure.

British medical bulletin • 2000

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