The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.

@article{Stabler1996TheUO,
  title={The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.},
  author={Sally P. Stabler and John Lindenbaum and Robert H. Allen},
  journal={The Journal of nutrition},
  year={1996},
  volume={126 4 Suppl},
  pages={1266S-72S}
}
Vitamin B-12 (cobalamin) is a cofactor for only two enzymes, methionine synthase and L-methylmalonyl-CoA mutase. The serum vitamin B-12 concentration has been shown to have limitations in specificity and sensitivity in diagnosing vitamin B-12 deficiency and predicting response to therapy in subjects with clinical deficiency syndromes. Serum methylmalonic acid and/or total homocysteine concentrations have been shown to be elevated in almost every patient who has a clinical response to vitamin B… CONTINUE READING
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