The use of herbal medicines in early drug development for the treatment of HIV infections and AIDS

@article{Liu2007TheUO,
  title={The use of herbal medicines in early drug development for the treatment of HIV infections and AIDS},
  author={Jianpin Liu},
  journal={Expert Opinion on Investigational Drugs},
  year={2007},
  volume={16},
  pages={1355 - 1364}
}
  • Jianpin Liu
  • Published 22 August 2007
  • Medicine, Biology
  • Expert Opinion on Investigational Drugs
This review systematically assesses the beneficial and harmful effects of herbal medicines in people with HIV infection and AIDS. Based on a Cochrane review and updated searches, the author identifies the available evidence on herbal medicines compared with placebo or antiretroviral drugs in patients with HIV infection, HIV-related disease or AIDS. There are ten randomised controlled trials, involving 571 individuals with HIV infection or AIDS, that met the inclusion criteria. Some herbal… 

Traditional Chinese Herbal Medicines for Treating HIV Infections and AIDS

TLDR
The overall methodological quality of the trials was adequate; however, randomization methods should be clearly described and fully reported in these trials according to the Consolidated Standards of Reporting Trials (CONSORT).

Progress on Research for the Treatment of HIV/AIDS with Traditional Chinese Medicine in China

TLDR
This paper reviews the recent progress in the use of TCM, from single herbs, herbal ingredients, compound Chinese herbal medicine, acupuncture and medical care, for the treatment of HIV/AIDS in China and reviews evaluation systems that assess the efficacy ofTCM.

Inhibition of HIV-1 Replication by Traditional Chinese Medicinal Herbal Extracts

TLDR
Four TCM extracts were demonstrated to be capable of preventing HIV-1 infection and replication by blocking viral entry and/or directly inhibiting the RT activity, suggesting the possibility of developing these extracts as potential anti-HIV therapeutic agents.

Inhibition of HIV-1 Replication by Traditional Chinese Medicinal Herbal

TLDR
Four TCM extracts were demonstrated to be capable of preventing HIV-1 infection and replication by blocking viral entry and/or directly inhibiting the RT activity, suggesting the possibility of developing these extracts as potential anti-HIV therapeutic agents.

Inhibition of HIV-1 Replication by Traditional Chinese Medicinal HerbalExtracts

TLDR
Four TCM extracts were demonstrated to be capable of preventing HIV-1 infection and replication by blocking viral entry and/or directly inhibiting the RT activity, suggesting the possibility of developing these extracts as potential anti-HIV therapeutic agents.

Inhibition of HIV-1 entry by extracts derived from traditional Chinese medicinal herbal plants

TLDR
This study characterized a panel of extracts of traditional Chinese medicinal herbal plants for their activities against HIV-1 replication and demonstrated that TXE and VAD inhibit HIV- 1 replication likely by blocking AIDS-1 interaction with target cells.

Is Chronic Combination Therapy of HAART and α-ZAM, Herbal Preparation for HIV Infection Safe?

TLDR
Nigerians like any other people in Africa are favourable to the use of herbal remedies for major illnesses, thus, that HIV infection has no cure medically serves as a catalyst to source for cure in herbal remedies.

Attitude of HIV patients to herbal remedy for HIV infection in Nigeria.

TLDR
The use of herbal remedy for HIV infection is high despite advice by medical doctors thus there is a need for caution when prescribing orthodox medicines that could interfere with hepatic metabolism.

Effect of traditional Chinese medicine for treating human immunodeficiency virus infections and acquired immune deficiency syndrome: Boosting immune and alleviating symptoms

TLDR
The Free TCM Program has made considerable progress in providing the necessary alternative care and treatment for HIV-infected people in China, and has strong government support for continued improvement and expansion, establishing and improving a work mechanism integrating Chinese and Western medicines.

References

SHOWING 1-10 OF 35 REFERENCES

Herbal medicines for treating HIV infection and AIDS.

TLDR
There is insufficient evidence to support the use of herbal medicines in HIV-infected individuals and AIDS patients, and potential beneficial effects need to be confirmed in large, rigorous trials.

Possible Drug–Metabolism Interactions of Medicinal Herbs with Antiretroviral Agents

TLDR
An overview of the modulating effects of Western and African herbal medicines on antiretroviral drug-metabolizing and transporting enzymes is provided, focusing on potential herb–antiret virus drug interactions.

How Effective are Complementary Therapies for HIV and AIDS?—a Systematic Review

TLDR
It is concluded that few rigorous trials of complementary treatments for HIV exist and stress management may prove to be an effective way to increase the quality of life.

Randomized, placebo-controlled trial of Chinese herb therapy for HIV-1-infected individuals.

TLDR
This standardized formulation of Chinese herbs for HIV-infected individuals did not improve quality of life, clinical manifestations, plasma virus loads, or CD4 cell counts, and no significant differences were found regarding plasma viral loads, symptoms, and psychometric parameters.

Pilot randomized controlled trial of Chinese herbal treatment for HIV-associated symptoms.

  • J. BurackM. R. CohenJ. HahnD. Abrams
  • Medicine
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1996
TLDR
Whether Chinese herbs are effective in the management of symptomatic HIV infection can be adequately addressed only by larger trials of longer duration.

HIV/AIDS: Traditional systems of health care in the management of a global epidemic.

TLDR
A growing body of research highlights the immunomodulatory and antiviral potential of plant-based medicines and partnerships between the modern and traditional/complementary health sectors in research, policy, and practice are essential in building comprehensive HIV/AIDS control strategies.

Impact of African herbal medicines on antiretroviral metabolism

TLDR
The effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold.

Complementary AIDS therapies: the good, the bad and the ugly

  • E. Ernst
  • Medicine
    International journal of STD & AIDS
  • 1997
TLDR
It is concluded that complementary therapies for HIV-infected/AIDS patients are popular, and their potential for doing either harm or good requires more detailed study.

Surveys of complementary and alternative medicine: part III. Use of alternative and complementary therapies for HIV/AIDS.

A series of 16 independent studies of the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) community and their use of alternative and complementary therapies over the past

Interactions between herbal medicines and prescribed drugs: a systematic review.

TLDR
Interactions between herbal medicines and synthetic drugs exist and can have serious clinical consequences, and healthcare professionals should ask their patients about the use of herbal products and consider the possibility of herb-drug interactions.