The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study

@article{Kim2011TheUO,
  title={The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study},
  author={Euitae Kim and O. Howes and Bo-Hyung Kim and Kyung-Sang Yu and J. Jeong and J. Lee and S. Kim and I. Jang and J. Park and Y. Kim and Sang-Goo Shin and F. Turkheimer and S. Kapur and J. Kwon},
  journal={Psychopharmacology},
  year={2011},
  volume={217},
  pages={515-523}
}
RationaleReceptor occupancy study has been performed to evaluate pharmacokinetic profiles in new antipsychotic drug development. While these findings highlight the value of positron emission tomography (PET) for dose-finding study, what is unclear is if it is necessary to conduct these studies in patients with schizophrenia or whether studies in healthy volunteers are adequate.ObjectivesTo determine if it is necessary to conduct dopamine receptor occupancy studies in patients with schizophrenia… Expand
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