The use of gold nanoparticles to enhance radiotherapy in mice.

@article{Hainfeld2004TheUO,
  title={The use of gold nanoparticles to enhance radiotherapy in mice.},
  author={J. Hainfeld and D. Slatkin and H. Smilowitz},
  journal={Physics in medicine and biology},
  year={2004},
  volume={49 18},
  pages={
          N309-15
        }
}
  • J. Hainfeld, D. Slatkin, H. Smilowitz
  • Published 2004
  • Chemistry, Medicine
  • Physics in medicine and biology
  • Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight), which elevated concentrations of gold to 7 mg Au/g in tumours. Tumour-to-normal-tissue gold concentration ratios remained approximately 8:1 during several minutes of 250 kVp x-ray therapy. One-year survival was 86% versus 20% with x-rays alone and 0% with gold alone. The increase in tumours safely ablated was dependent on the amount of… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Gold microspheres: a selective technique for producing biologically effective dose enhancement.
    • 243
    Cure of Fisher Rats Bearing Radioresistant F98 Glioma Treated with cis-Platinum and Irradiated with Monochromatic Synchrotron X-Rays
    • 166
    • PDF
    Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    • 3,177
    • PDF
    Radiation dose enhancement in tumors with iodine.
    • 143
    First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx).
    • 90
    X-ray phototherapy for canine brain masses.
    • 66
    The influence of energy absorption and electron range on dosage in irradiated bone.
    • F. Spiers
    • Mathematics, Medicine
    • The British journal of radiology
    • 1949
    • 140