The use of gold nanoparticles to enhance radiotherapy in mice.

  title={The use of gold nanoparticles to enhance radiotherapy in mice.},
  author={J. Hainfeld and D. Slatkin and H. Smilowitz},
  journal={Physics in medicine and biology},
  volume={49 18},
  • J. Hainfeld, D. Slatkin, H. Smilowitz
  • Published 2004
  • Chemistry, Medicine
  • Physics in medicine and biology
  • Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight), which elevated concentrations of gold to 7 mg Au/g in tumours. Tumour-to-normal-tissue gold concentration ratios remained approximately 8:1 during several minutes of 250 kVp x-ray therapy. One-year survival was 86% versus 20% with x-rays alone and 0% with gold alone. The increase in tumours safely ablated was dependent on the amount of… CONTINUE READING
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