The use of genetically altered astrocytes to provide nerve growth factor to adrenal chromaffin cells grafted into the striatum.

Abstract

Transplantation of adrenal chromaffin cells into the striatum of Parkinson's disease patients is unlikely to become a reliable therapy unless techniques are devised to improve cell survival. To address this issue, we investigated the use of genetically altered astrocytes that constitutively secrete beta-nerve growth factor (NGF) to provide trophic support… (More)

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