The use of formulation technology to assess regional gastrointestinal drug absorption in humans.

@article{Basit2004TheUO,
  title={The use of formulation technology to assess regional gastrointestinal drug absorption in humans.},
  author={Abdul W. Basit and Fridrun Podczeck and J. M. Newton and Wendy A. Waddington and Peter Joseph Ell and Larry F. Lacey},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2004},
  volume={21 2-3},
  pages={179-89}
}
The aim of this study was to assess the feasibility of using oral modified-release formulations for the purposes of site-specific targeting and regional drug absorption assessment in man. An immediate release pellet formulation containing ranitidine as the model drug of choice for the study was fabricated by extrusion-spheronisation, and then film coated with either the enteric polymer polyvinyl acetate phthalate or the bacteria-degradable polymer amylose, in combination with ethylcellulose, to… CONTINUE READING

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