The use of fluorescent probes to characterize conformational changes in the interaction between vitronectin and plasminogen activator inhibitor-1.

@article{Gibson1997TheUO,
  title={The use of fluorescent probes to characterize conformational changes in the interaction between vitronectin and plasminogen activator inhibitor-1.},
  author={Adele Gibson and K Baburaj and Duane E Day and Ingrid M Verhamme and Joseph D. Shore and Cynthia B. Peterson},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 8},
  pages={5112-21}
}
Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of tissue-type plasminogen activator and urokinase, is known to convert readily to a latent form by insertion of the reactive center loop into a central beta-sheet. Interaction with vitronectin stabilizes PAI-1 and decreases the rate of conversion to the latent form, but conformational effects of vitronectin on the reactive center loop of PAI-1 have not been documented. Mutant forms of PAI-1 were designed with a cysteine… CONTINUE READING

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Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin.

European journal of biochemistry • 2002
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