The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage.

@article{Evans1991TheUO,
  title={The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage.},
  author={James W. Evans and J. A. Chang and Amato J. Giaccia and Dan Pinkel and Jeremy M. Brown},
  journal={British Journal of Cancer},
  year={1991},
  volume={63},
  pages={517 - 521}
}
The technique of fusing mitotic cells to interphase cells, thereby producing condensation of the chromosomes of the interphase cell (so-called 'premature chromosome condensation' or PCC), has allowed detection of the initial number of chromosome breaks and their repair following ionising radiation. However, the difficulty and tedium of scoring all the chromosome fragments, as well as the inability to readily detect exchange aberrations, has limited the use of PCC. We describe here the use of… CONTINUE READING

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