The use of first polar bodies for preimplantation diagnosis of aneuploidy.

@article{Munn1995TheUO,
  title={The use of first polar bodies for preimplantation diagnosis of aneuploidy.},
  author={Santiago Munn{\'e} and Theresa Dailey and Khalid M. Sultan and Jamie A. Grifo and Jacques Cohen},
  journal={Human reproduction},
  year={1995},
  volume={10 4},
  pages={1014-20}
}
A large proportion of patients undergoing in-vitro fertilization (IVF) are aged > or = 35 years. It has been estimated that in this age group, 50% of embryos are chromosomally abnormal, with aneuploidy being the major contributing factor. Since the origin of most aneuploidies is maternal meiosis I non-disjunction, unfertilized oocytes could be safely screened for aneuploidy by analysing their first polar bodies. To determine the feasibility of first polar body aneuploidy analysis, polar bodies… CONTINUE READING

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