The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model.

@article{Higdon2001TheUO,
  title={The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model.},
  author={Kent K. Higdon and Anthony D. Scott and Michelle A. Tucci and Hamed A. Benghuzzi and Audrey Tsao and Aaron Puckett and Zelma Cason and J M Lynne Hughes},
  journal={Biomedical sciences instrumentation},
  year={2001},
  volume={37},
  pages={281-6}
}
It is well established that the pattern of bone loss from the cortex in osteoporotic bone begins from the endosteal surface of the cortex, where there is enlargement of the medullary canal at the expense of the inner cortex. Bone loss does not occur at the periosteal surface. The objective of the following study was to induce osteoporosis in female rats by ovariectomy, followed by treatment with sustained delivery of Diosgenin (DG), dehydroepiandrosterone (DHEA), or estrogen (E) after clinical… CONTINUE READING
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