The use of ebastine, a mast cell blocker, for treatment of oligozoospermia.

@article{Matsuki2000TheUO,
  title={The use of ebastine, a mast cell blocker, for treatment of oligozoospermia.},
  author={Shingo Matsuki and Isoji Sasagawa and Yasuhiro Suzuki and Hiroki Yazawa and Tadashi Tateno and Tatsuo Hashimoto and Teruhiro Nakada and Hidekazu Saito and Masahiko Hiroi},
  journal={Archives of andrology},
  year={2000},
  volume={44 2},
  pages={129-32}
}
The effect of mast cell blocker (ebastine) on semen quality was evaluated in 15 idiopathic oligozoospermic males. Ten milligrams/day of ebastine was administered orally for 3 months. Nine cases (66.7%) showed definite improvement in the semen quality. The wives of 3 patients (20%) became pregnant within 6 months of the initial treatment. It would appear that mast cell blocker (ebastine) significantly improves semen quality in men with idiopathic oligozoospermia.