The use of chloride–sodium ratio in the evaluation of metabolic acidosis in critically ill neonates


Acid–base disturbances have been usually evaluated with the traditional Henderson–Hasselbach method and Stewart’s physiochemical approach by quantifying anions of tissue acids (TA). It is hypothesized that an increase in tissue acids during metabolic acidosis would cause a compensatory decrease in the plasma chloride (Cl) relative to sodium (Cl–Na ratio) in… (More)
DOI: 10.1007/s00431-011-1666-4


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