The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules.

@article{Teply2008TheUO,
  title={The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules.},
  author={Benjamin A. Teply and Rong Tong and Seok Yoon Jeong and Gaurav Aman Luther and Ines Sherifi and Christopher H. Yim and Ali Khademhosseini and Omid C Farokhzad and Robert S Langer and Jianjun Cheng},
  journal={Biomaterials},
  year={2008},
  volume={29 9},
  pages={
          1216-23
        }
}
Protein drugs have low bioavailability after oral administration, which is due in part to fast transit of the drugs or drug delivery vehicles through the gastrointestinal tract. Increasing the time that the drugs spend in the intestine after dosing would allow for greater absorption and increased bioavailability. We developed a formulation strategy that can be used to prolong intestinal retention of drug delivery vehicles without substantial alterations to current polymeric encapsulation… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

Magnetic nanoparticles for drug delivery. Nano Today 2007;2:22e32

  • M Arruebo, R Fernandez-Pacheco, MR Ibarra, J. Santamaria
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…