The use of calnexin and calreticulin by cellular and viral glycoproteins.

  title={The use of calnexin and calreticulin by cellular and viral glycoproteins.},
  author={Michel Pieren and Carmela Galli and Angela Denzel and Maurizio Molinari},
  journal={The Journal of biological chemistry},
  volume={280 31},
Calnexin and calreticulin are homologous lectin chaperones that assist maturation of cellular and viral glycoproteins in the mammalian endoplasmic reticulum. Calnexin and calreticulin share the same specificity for monoglucosylated protein-bound N-glycans but associate with a distinct set of newly synthesized polypeptides. We report here that most calnexin substrates do not associate with calreticulin even upon selective calnexin inactivation, while BiP associates more abundantly with nascent… CONTINUE READING

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