The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.

@article{Berglund2003TheUO,
  title={The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.},
  author={Magnus M. Berglund and Douglas A Schober and Michael A. Statnick and Patricia H. McDonald and Donald R. Gehlert},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={306 1},
  pages={147-56}
}
The neuropeptide Y (NPY) family peptides NPY, peptide YY (PYY), and pancreatic polypeptide (PP) bind to four G protein-coupled receptors (GPCRs): Y1, Y2, Y4, and Y5. A key step in the desensitization and internalization of GPCRs is the association of the receptor with beta-arrestins. In the present study, these receptors were analyzed with respect to their ability to interact with GFP2-tagged beta-arrestin 2 using the new bioluminescence resonance energy transfer 2 method. Agonists induced a… CONTINUE READING

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