The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis.

@article{Kim2011TheUO,
  title={The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis.},
  author={Jae-Hwan Kim and Ji Sun Park and Han Na Yang and Dae Gyun Woo and Su Yeon Jeon and Hong Nhung Do and Hye-Young Lim and Jung Mo Kim and Keun-Hong Park},
  journal={Biomaterials},
  year={2011},
  volume={32 1},
  pages={
          268-78
        }
}
In stem cell therapy, transfection of specific genes into stem cells is an important technique to induce cell differentiation. To perform gene transfection in human mesenchymal stem cells (hMSCs), we designed and fabricated a non-viral vector system for specific stem cell differentiation. Several kinds of gene carriers were evaluated with regard to their transfection efficiency and their ability to enhance hMSCs differentiation. Of these delivery vehicles, biodegradable poly (DL-lactic-co… CONTINUE READING

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Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics.

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