The use of base pair specific DNA binding agents as affinity labels for the study of mammalian chromosomes

@article{Jorgenson1978TheUO,
  title={The use of base pair specific DNA binding agents as affinity labels for the study of mammalian chromosomes},
  author={K. F. Jorgenson and Johan H. van de Sande and Cheng Chieh Lin},
  journal={Chromosoma},
  year={1978},
  volume={68},
  pages={287-302}
}
The fluorochromes Hoechst 33258 and olivomycin are base pair specific DNA binding agents. The fluorescence enhancement of Hoechst 33258 and olivomycin in the presence of DNA can be directly related to the A-T and G-C content of the interacting DNA respectively. Cytological observations of metaphase chromosomes treated with these two compounds suggest that the fluorescent banding patterns produced are the reverse of one another. —Non-fluorescent base pair specific DNA binding agents have been… CONTINUE READING
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The use of antinucteoside antibodies to probe the organization of chromosomes denatured by ultraviolet irradiation

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