The use of antibody-secreting cell probes to reveal tissue-restricted immune responses during infection.

@article{Meeusen1994TheUO,
  title={The use of antibody-secreting cell probes to reveal tissue-restricted immune responses during infection.},
  author={Els N T Meeusen and Malcolm R. Brandon},
  journal={European journal of immunology},
  year={1994},
  volume={24 2},
  pages={469-74}
}
Antibody secreting cell probes (ASC-probes) were generated from the hepatic lymph node (HLN), mesenteric lymph node (MLN) and spleen of rats after infection with the liver fluke, Fasciola hepatica, and used to probe Western blots of parasite antigens. In chronic primary infections, parasite-specific antibodies were only detected in ASC-probes derived from HLN. Seven days after a secondary infection, a restricted response was detected in ASC-probes from the MLN, directed predominantly against an… CONTINUE READING

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