The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells.

@article{Riddell1990TheUO,
  title={The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells.},
  author={Stanley R Riddell and Philip D. Greenberg},
  journal={Journal of immunological methods},
  year={1990},
  volume={128 2},
  pages={189-201}
}
Antigen-specific T cell clones are useful reagents for studies of the fine specificity of antigen recognition and of potential therapeutic use in adoptive immunotherapy for human viral and malignant diseases. Culture methods which require antigen and APC for stimulation can be problematic for the generation and long-term growth of human virus and tumor-specific T cells. We have developed an alternative culture method using monoclonal antibodies to T cell activation molecules, CD3 and CD28, as… CONTINUE READING
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