The use of a cell-cycle phase-marker may decrease the percentage of errors when using FISH in PGD.

@article{Pujol2004TheUO,
  title={The use of a cell-cycle phase-marker may decrease the percentage of errors when using FISH in PGD.},
  author={Alba Pujol and J Benet and Merc{\`e} Campillo and Montserrat Codina-Pascual and Josep Egozcue and Jhonilys Navarro},
  journal={Cytogenetic and genome research},
  year={2004},
  volume={105 1},
  pages={29-35}
}
Fluorescent DNA probes are used to characterise the chromosome constitution of preimplantation embryos. FISH is used to select normal or balanced embryos in carriers of balanced chromosomal rearrangements, for embryo sexing or for aneuploidy screening in women of advanced age, who have had recurrent abortions or IVF failures. In most cases, FISH is performed on interphase blastomeres which are asynchronously dividing cells, that can be in G1, S or G2. However, a correct interpretation of a… CONTINUE READING