The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein

@article{Benton2002TheUO,
  title={The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein},
  author={Trish Benton and Tim Chen and Michele McEntee and Brian Fox and David King and Robert Crombie and Thomas C. Thomas and Christopher R Bebbington},
  journal={Cytotechnology},
  year={2002},
  volume={38},
  pages={43-46}
}
UCOE vectors contain non-tissue specific chromatin-opening-elements that permit rapid expression of a protein in anintegration independent manner. Efficient expression can bederived from a single copy of an integrated gene site resulting ina higher percentage of cells expressing the marker gene in theselected pool in comparison to standard non-UCOE containingvectors. This, in combination with the utilization of a serum-free, suspension adapted parent cell line allows for rapidproduction of… CONTINUE READING