Idiosyncratic quinoline central nervous system toxicity: Historical insights into the chronic neurological sequelae of mefloquine☆
- Remington L. Nevin
- International journal for parasitology. Drugs and…
A large number of piperidyl quinolinemethanols were investigated for antimalarial activity in avian infections because of close chemical similarity to quinine, as part of the wartime search for new and more effective antimalarial agents. In preliminary observations, SN-10,275,3 or 6,8-dichloro-2phenyl-a-2-piperidyl4-quinolinemethanol (Figure 1), gave greatest indication of promise. It is a compound of the Ainley-King series, which has a high degree of antimalarial activity in cathemerium and lophurae malaria in the duck and moderate activity in gallinaceum and lophurae malaria in the chick ( 1 ).