The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene.

@article{Farmer2005TheUO,
  title={The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene.},
  author={Peter B. Farmer and Balvinder Kaur and Jonathan Roach and L. B. Levy and Dario Consonni and Pietro Alberto Bertazzi and Angela Cecilia Pesatori and Silvia Fustinoni and Marina Buratti and Matteo Bonzini and Antonio Colombi and Todor Popov and Domenico M. Cavallo and Arianna Desideri and Federico Valerio and Mauro Pala and Claudia Bolognesi and Franco Merlo},
  journal={Chemico-biological interactions},
  year={2005},
  volume={153-154},
  pages={97-102}
}
S-Phenylmercapturic acid (S-PMA), is a urinary metabolite of benzene, thought to be derived from the condensation product of benzene oxide with glutathione. S-PMA may be determined by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassays. The limit of sensitivities of most of these techniques is 1 microg/l urine or below. It has been suggested that S-PMA may have value as a biomarker for low level human exposure to benzene, in view of the facts that urinary excretion of S-PMA… CONTINUE READING
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