The use of PET and knockout mice in the drug discovery process.

Abstract

Although [15O]H(2)O, 2-[18F]fluoro-2-deoxyglucose (FDG) and other radioligands for low-density receptors and enzymes have been used in drug discovery and drug development, the impact on the pharmaceutical industry, to date, has been anecdotal. As new chemical entities are developed, radiotracers that aid in characterizing these drugs need to be developed… (More)

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Cite this paper

@article{Eckelman2003TheUO, title={The use of PET and knockout mice in the drug discovery process.}, author={William C. Eckelman}, journal={Drug discovery today}, year={2003}, volume={8 9}, pages={404-10} }