The use of 99mTc-phytate for assessment the protective effect of vitamin E against hepatotoxicity induced by methotrexat in rat.

@article{Amirfakhrian2018TheUO,
  title={The use of 99mTc-phytate for assessment the protective effect of vitamin E against hepatotoxicity induced by methotrexat in rat.},
  author={Hossein Amirfakhrian and S. Abedi and H. Sadeghi and Soheil Azizi and S. Hosseinimehr},
  journal={Nuclear medicine review. Central & Eastern Europe},
  year={2018},
  volume={21 1},
  pages={
          8-13
        }
}
  • Hossein Amirfakhrian, S. Abedi, +2 authors S. Hosseinimehr
  • Published 2018
  • Medicine
  • Nuclear medicine review. Central & Eastern Europe
  • In this study, we investigated the protective effect of vitamin E against methotrexate (MTX)-induced hepatotoxicity by quantitative liver 99mTc-phytate uptake and liver imaging and to compare its effect with histopathology in rat. Rats were divided into five groups as control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg), Vit E + MTX and. Vit E was intraperitoneally administrated for 17 days before MTX injection and continued for 4 days. 99mTc-phytate was injected through the tail of rats after… CONTINUE READING

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