The use of 111in-labeled lymphocyte imaging to evaluate graft rejection following cardiac transplantation in dogs

@article{Mckillop1982TheUO,
  title={The use of 111in-labeled lymphocyte imaging to evaluate graft rejection following cardiac transplantation in dogs},
  author={J H Mckillop and John Wallwork and Bruce A. Reitz and Margaret E. Billingham and Richard Miller and Ian Ross McDougall},
  journal={European Journal of Nuclear Medicine},
  year={1982},
  volume={7},
  pages={162-165}
}
Lymphocytes separated from venous blood from six dogs who had heterotopic cardiac transplants have been labeled using 111In-oxine. Labeled lymphocytes were reinjected into the dogs and imaging of the heart carried out over the successive 3 or 4 days. For comparison serial ECGs and punch biopsies of the heart were obtained. Abnormal uptake of labeled lymphocytes in the donor heart was clearly visible in three of the six dogs, faintly visible in two and not seen in one. 630 μCi 111In was used in… CONTINUE READING

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