The use of 10-23 DNAzyme to selectively destroy the allele of mRNA with a unique purine-pyrimidine dinucleotide.

Abstract

10-23 DNAzyme is an oligodeoxyribonucleotide-based ribonuclease. It consists of a 15-nt catalytic domain flanked by two target-specific complementary arms. It has been shown to cleave target mRNA effectively at purine (R)-pyrimidine (Y) dinucleotide. Taking advantage of this specific property, 10-23 DNAzyme was designed to cleave mRNA of a given allele at a… (More)
DOI: 10.1089/oli.2008.0138

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Cite this paper

@article{Wang2008TheUO, title={The use of 10-23 DNAzyme to selectively destroy the allele of mRNA with a unique purine-pyrimidine dinucleotide.}, author={Tong-Hong Wang and Wan-Ting Li and Szu-Hsien Yu and L C Au}, journal={Oligonucleotides}, year={2008}, volume={18 3}, pages={295-9} }