The use and safety of doxycycline hyclate and other second-generation tetracyclines

@article{Sloan2008TheUA,
  title={The use and safety of doxycycline hyclate and other second-generation tetracyclines},
  author={Barry Sloan and Noah S. Scheinfeld},
  journal={Expert Opinion on Drug Safety},
  year={2008},
  volume={7},
  pages={571 - 577}
}
Tetracyclines have long been used to treat a wide variety of medical conditions, especially in the field of dermatology. Unfortunately, safety concerns, especially gastrointestinal (GI), have always been present. Other safety concerns have included tooth development in children, candidiasis, vestibular concerns, photosensitivity/phototoxicity, and more unusual adverse effects such as uncontrolled hypertension. This article first discusses the pharmacological development of the tetracyclines… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
A status report on the use of subantimicrobial-dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines.
TLDR
Enhanced understanding of inflammatory pathways in epithelial and mesenchymal tissues has revealed that the use of subantimicrobial doses of doxycycline initiates anti-inflammatory activity that correlates with clinical efficacy in acne vulgaris and rosacea. Expand
Second-generation tetracyclines, a dermatologic overview: clinical uses and pharmacology.
TLDR
The important pharmacologic and microbiological characteristics of these three commonly used second-generation tetracyclines minocycline, doxycycline hyclate, and doxy cycline monohydrate are reviewed, and their clinical applications in dermatology are reviewed. Expand
Recently approved systemic therapies for acne vulgaris and rosacea.
TLDR
The studies and clinical applications related to the use of tetracycline derivatives and minocycline was discussed, based on large-scale phase 3 pivotal trials and long-term microbiologic and safety data. Expand
Recently approved systemic therapies for acne vulgaris and rosacea.
TLDR
The studies and clinical applications related to the use of tetracycline derivatives and minocycline was discussed, based on large-scale phase 3 pivotal trials and long-term microbiologic and safety data. Expand
Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne.
TLDR
Twice-daily SD doxycycline treatment significantly reduced the number of inflammatory and noninflammatory lesions in patients with moderate facial acne, was well tolerated, had no detectable antimicrobial effect on the skin flora, and did not result in any increase in the number or severity of resistant organisms. Expand
Systemic Antibiotics for Acne
TLDR
Systemic antibiotics are indicated as treatment of moderate and quite severe acne or if acne is considered as very serious by the patient for psychological or social reasons, and during pregnancy the best antibiotic is erythromycin. Expand
Safety and efficacy of a new extended-release formulation of minocycline.
TLDR
It was concluded that a novel ER-minocycline formulation that delivers consistent levels of drug at a 1-mg/kg dose reduces dose-dependent AVAEs while reducing inflammatory lesions and improving the overall appearance of patients with acne vulgaris. Expand
Interaction of Doxycycline and Warfarin: An Enhanced Anticoagulant Effect
TLDR
Doxycycline can enhance the anticoagulant effect of warfarin and is likely due to competitive interaction for albumin binding and possibly inhibition of the cytochrome P-450 system. Expand
Porphyria-like cutaneous changes induced by tetracycline hydrochloride photosensitization.
TLDR
Five patients manifested cutaneous changes indistinguishable from those noted in some porphyric disorders, consisting of fragility, denudation, and blister formation of sun-exposed skin, which were concluded to result from a low-grade photosensitization by tetracycline hydrochloride. Expand
Evaluation of Periostat for patient management.
  • J. Caton
  • Medicine
  • Compendium of continuing education in dentistry
  • 1999
TLDR
The clinical trial results leading to US Food and Drug Administration approved of Periostat are reviewed and the potential use of this host-modulatory agent as a complementary systemic pharmacotherapy in periodontal management programs is discussed. Expand
...
1
2
3
4
...