The use and safety of doxycycline hyclate and other second-generation tetracyclines

  title={The use and safety of doxycycline hyclate and other second-generation tetracyclines},
  author={Barry Sloan and Noah S. Scheinfeld},
  journal={Expert Opinion on Drug Safety},
  pages={571 - 577}
Tetracyclines have long been used to treat a wide variety of medical conditions, especially in the field of dermatology. Unfortunately, safety concerns, especially gastrointestinal (GI), have always been present. Other safety concerns have included tooth development in children, candidiasis, vestibular concerns, photosensitivity/phototoxicity, and more unusual adverse effects such as uncontrolled hypertension. This article first discusses the pharmacological development of the tetracyclines… 

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