The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis

@article{Mazar1999TheUP,
  title={The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis},
  author={Andrew P. Mazar and Jack Henkin and Ronald H. Goldfarb},
  journal={Angiogenesis},
  year={1999},
  volume={3},
  pages={15-32}
}
Substantial evidence exists which implicates the urokinase plasminogen activator system [urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1)] in the neo-vascularization, invasion and metastasis of many solid tumors. Clinical studies have demonstrated an association between high levels of expression of the components of this system in tumors and poor patient prognosis and outcome. Components of the uPA/uPAR system… CONTINUE READING
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