The urokinase plasminogen activator receptor as a gene therapy target for cancer.

@article{Pillay2007TheUP,
  title={The urokinase plasminogen activator receptor as a gene therapy target for cancer.},
  author={Vinochani Pillay and Crispin R Dass and Peter Choong},
  journal={Trends in biotechnology},
  year={2007},
  volume={25 1},
  pages={33-9}
}
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. Impairment of uPA and/or uPAR function, or inhibition of the expression of these components, impedes the metastatic potential of many tumours. Several approaches have been employed to target uPAR with the aim of disrupting its ligand-independent action or interaction with uPA, including… CONTINUE READING

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